Abstract Background Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy.A promising strategy is CRISPR-Cas9-mediated precise insertion of F8 in hepatocytes at highly expressed gene loci, such as albumin (Alb).Unfortunately, the precise in vivo integration efficiency of a long insert is very low (~ 0.1%
Modern offworld drum pads surveys of ectoparasites and potential vector-borne pathogens in the Republic of the Marshall Islands and Wake Island are poorly documented.We report on field surveys of ectoparasites from 2010 with collections from dogs, cats, and rats.Five ectoparasites were identified: the cat flea Ctenocephalides felis, a sucking louse
Background: This study explored the perceptions of older adults on the use of a custom built interactive video game (IVG) in promoting health and well-being ashy bines protein powder among the older adult population.Method: This qualitative study used a phenomenological approach and enrolled 10 older adults over the age of 65 years in a client cent
The rapid development of information systems generates new needs for indexing getpureroutine.com and retrieval of various kinds of media.The need for documents in the form of multimedia is increasing currently.Thus, the need to store or retrieve now becomes a primary problem.The multimedia type commonly used is text types, as widely seen as the mai
Papillomaviruses (PVs) are well established to cause hyperplastic papillomas (warts) in humans and animals.In addition, due to their ability to alter cell regulation, PVs are also recognized to cause approximately 5% of human cancers and these viruses have been associated with neoplasia in a number of animal species.In contrast to other domestic sp